Endocrine Abstracts

An increasing body of evidence demonstrates that growth factor networks are highly interactive with oestrogen receptor (ER) signalling in the pathogenesis of a number of common cancer types, including breast cancer. Thus several growth factor-induced protein kinases are able to target and phosphorylate key regulatory sites within the ER and its co-activating proteins, a process that enables the activity of the ER as a nuclear transcription factor. It is believed that when aber...